This frequently contested showdown has been well balanced this century with Panathinaikos leading 14-11 overall. Fourteen of the last 16 meetings have been won by the home team.
The last time they met in Athens, in Round 4 of last season, Panathinaikos guard Nikos Pappas scored the last of his 24 points with a late game-winner to seal a 70-68 triumph.
When these two team met in the 2017 EuroLeague Playoffs, Fenerbahce became the first team to sweep a best-of-five playoff series without having home-court advantage.
Panathinaikos hit a club EuroLeague record 18 three-point shots against Fenerbahce in October 2014.
Zeljko Obradovic cemented his status as a coaching legend during his 13 seasons with Panathinaikos. During that time he led the Greens to five EuroLeague titles, 11 Greek League championships and seven Greek Cups.
Panathinaikos big man Ian Vougioukas played under Coach Obradovic at Panathinaikos from 2010 to 2012; they won the 2011 EuroLeague title together.
Panathinaikos forward James Gist played for Fenerbahce during the 2011-12 season.
Panathinaikos guard Keith Langford and Fenerbahce forward Nicolo Melli were teammates at Olimpia Milan during the 2012-13 season.
Panathinaikos big man Stephane Lasme and Fenerbahce guard Sinan Guler were teammates at Galatasaray Istanbul during the 2015-16 season. They won the 7DAYS EuroCup title together.
Vougioukas was a teammate of Guler at Galatasaray for the first part of the 2014-15 season.
Kostas Sloukas and Panathinaikos players Matt Lojeski and Ioannis Papapetrou were teammates at Olympiacos Piraeus for two seasons, from 2013 to 2015.
Fenerbahce guard Erick Green and Panathinaikos players Lojeski and Papapetrou were teammates at Olympiacos for the 2016-17 season.
Nick Calathes, Papapetrou and Vougioukas have been teammates of Sloukas on the Greek national team.
Jan Vesely of Fenerbahce and Stephane Lasme of Panathinaikos were teammates at Partizan Belgrade for the 2008-09 season.
Vesely and Gist were teammates at Partizan Belgrade during the 2010-11 season.
Fenerbahce big man Ahmet Duverioglu set his career-high with 13 points and posted his career-high index rating of 15 against Panathinaikos in January 2017.
Panathinaikos forward James Gist set his career-high in offensive rebounds with 7 in a 77-72 road loss against Fenerbahce in January of 2014, and matched his career high with 5 assists in an 84-62 road loss against Fenerbahce in December of the same year.